Geron Corporation /quotes/comstock/15*!gern/quotes/nls/gern (GERN 5.33, +0.53, +11.04%) announced today that the U.S. Food and Drug Administration (FDA) has notified the company that the clinical hold placed on Geron's Investigational New Drug (IND) application has been lifted and the company's Phase I clinical trial of GRNOPC1 in patients with acute spinal cord injury may proceed.

Conditionally replicating adenoviruses (CRAds) represent a promising modality for the treatment of neoplastic diseases, including Prostate Cancer. Selectively replicating viruses can be generated by placing a tissue or cancer-specific promoter upstream of one or more of the viral genes required for replication (for example, E1A, E1B).

Hemophilia A and B are attractive target diseases for gene therapy, as stable expression of coagulation factor VIII and IX may correct the bleeding diathesis.

Journal of Genetic Syndromes & Gene Therapy (JGSGT), a broad-based journal was founded on two key tenets: To publish the most exciting researches with respect to the subjects of Genetic Syndrome & Gene Therapy. Secondly, to provide a rapid turn-around time possible for reviewing and publishing, and to disseminate the articles freely for research, teaching and reference purposes.


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What if you could not only beat cancer, but watch your body do it? Researchers at UCLA’s Jonsson Comprehensive Cancer Center are using gene therapy to teach immune cells how to attack cancer, but that’s now all. By inserting a “reporter gene” that glows under a Positron Emission Tomography (PET) scan, researchers can watch in real-time as the genetically modified immune cells seek out and destroy tumors within the body.

Radiofrequency ablation (RFA) is a minimally invasive tumor destruction technique and can provide the antigen source initiating tumor immunity. However, induced immune response is weak and requires additional immunotherapy for optimized RFA treatment against cancer.

The development of efficient and specific vector systems remains a central issue in gene therapy. Several different adeno-associated virus (AAV) serotypes have so far been characterized so far which show different tissue tropisms.

Pancreatic cancer (PC) is a highly lethal disease with complex etiology involving both environmental and genetic factors.

WEDNESDAY, July 21 (HealthDay News) -- Eight of nine male infants born with so-called "Bubble Boy" disease were still alive and well nine years after they underwent gene therapy, French researchers report.

A novel technique created at UCSF to deliver a growth factor directly to brain cells has shown promising results in treating Parkinson’s symptoms and could enter human clinical trials as early as next year.

Objective. To review the basic principles and primary issues regarding the healing of allograft bone. To review progress made in understanding the molecular mechanisms of healing, and efforts being made to manipulate these processes to enhance healing.